Mena, 31, was married to the 18-years-older cinematographer Robert Brinkmann from 2000 to 2006.
This time around she has chosen someone closer to her in age, in 25-year old concert producer Simone Sestito.
The pair, who got engaged in 2008, chose a private chapel within the Vatican City for their ceremony as most of the groom's family live around Rome.
After the wedding the couple threw a private reception at Castello Odescalchi, in Bracciano
Mena went to great lengths to keep her new husbands family happy.
She revealed to OK! magazine in an interview last year how she planned to have her wedding dress customised to cover her tattoos.
